Ssa Antibody Reference Range

A positive anti ro result is revealed and known by a speckled appearance under immune fluorescence with ultraviolet light.

Ssa antibody reference range.

Antibodies to ena are common in patients with connective tissue diseases systemic rheumatic diseases. Anti ro antibodies also known as anti ssa antibodies are associated with sjögren syndrome. Sjogren s antibodies ss a ss b sjögren s antibodies ss b is detected in approximately 15 of patients with sjögren s syndrome. Ss a ro antibodies are associated with childhood le neonatal le and with congenital heart block in infants born to mothers with le 1 2 ss a ro antibodies have also been reported to be associated with features of extraglandular inflammation in patients with le including vasculitis purpura cytopenias and adenopathy.

Anti ro levels may be elevated in the following conditions. 60 70 of cases systemic lupus erythematosus sle. Patients with ss a may also have antibodies to cardiolipin lupus anticoagulant and clinical thromboses. Ss a ro ss b la rnp and sm are autoantigens commonly referred to as extractable nuclear antigens ena.

Ss a ro antibodies occur in patients with several different connective tissue diseases including sjogren syndrome an autoimmune disease that involves primarily the salivary and lachrymal glands up to 90 of cases. Anti ss a and anti ss b are found in virtually all children with neonatal lupus. Antibodies to ss a are also associated with hla loci dr3 and dr2 and with hereditary deficiency of c2. Sjögren s antibody ss b is present only if sjögren s antibody ss a is also detected.

25 of cases both anti ro ssa and. Ss a ro is an extractable nuclear antigen ena composed of protein antigens of 52 kd and 60 kd combined with cytoplasmic rna species. Lupus erythematosus le 40 60 of. The reference range of anti ro antibodies is negative.

Ss a ro is composed of protein antigens of 52 kd and 60 kd combined with cytoplasmic rna species. This has been termed antiphospholipid antibody syndrome. Ss a ro antibodies occur in patients with several different connective tissue. The presence of both antibodies ss a and ss b strengthen the diagnosis of sjögren s syndrome and conveys prognostic information.